![]() ![]() If making the origami stem version, your tulip will be able to stand too and will have leaves (watch the video on auto play for this part of the tutorial)!Īren’t these Paper Tulips simply adorable? I think they make a great origami project for any age group… but are especially a lovely Preschool Spring Craft don’t you think? They would look lovely on mother’s day cards! Or make a bunch as a small bouquet to give to mom. Cut a snip into the bottom of the tulip head and insert. Using a tooth pick or a thin paint brush to get it going should help. Take the green paper and start rolling it up diagonally. However, you can also choose this other rolled up paper straw method. The video shared in this blogpost shows you how to make an ORIGAMI stem. Our origami models that are categorised as easy also include models that are easy to intermediate. Some easy origami models are not too easy, which means if you’re a complete beginner, you may want to have a go at some origami base folds for beginners first.
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![]() ![]() My parents are beekeepers and this song makes me thing of the time growing up in the Minco bee yards. From hearing the banjo in "Rainbow Connection" to the harmonies and use of brass in "Keep the Customer Satisfied" to the painful lyrics of "Father and Son" these albums shaped me.įind a song of yours on Apple Music that you love and tell us what makes it special. ![]() Doubling as a dairy powerhouse, you'll also get your hands on Minco's cheeses, milks and more. minco oklahma questions WebAs many know this coming Saturday is the Minco Honey festival. Without dealing with those pesky, winged nightmares, you'll get to sample Minco's sweet honey and all of their honey-themed products. WebR & M Arms LLC Store Address: 208 Main St, Minco, OK 73059. Minco hosts an annual Honey Festival every December. These albums all had songs or moments that shaped me as a musician. Everfest's Take The kind volunteers of Minco, Oklahoma, battled many gangs of bees to bring you the Honey Festival. Minco, OK Map & Directions - MapQuest Opony Specialized Purgatory i Butcher GRID 2br - Allegro. Various Artists, The Muppet Movie (Original Motion Picture Soundtrack) Simon & Ga******l, Bridge Over Troubled Water MINCO, OKLAHOMA Thousands of visitors swarmed into shops and restaurants for the 21st annual Minco Honey Festival for an old-fashioned Christmas celebration. What are your top 3 all-time favorite albums on Apple Music, and why? Why did you choose these three albums in particular?Ĭat Stevens, Footsteps in the Dark - Greatest Hits, Vol. Please contact the Minco Chamber of Commerce for more information at (405) 352-0518 and ask for Nancy or Deana.Ĭontestants must be in Kindergarten, 1st, 2nd, or 3rd grade, and a Minco resident.Describe one of your earliest musical memories in detail.įirst performed for an audience at 9 singing Ray Stevens's "The Streak" at the first Minco Honey Festival. It is a day to enjoy a feeling of an Old Fashioned Christmas in Minco, Oklahoma located on Highway 81 between El Reno and Chickasha, just 30 minutes southwest of Oklahoma City.Īnd tasty recipes that use honey? These are great: HONEY RECIPES (PDF format) An estimated 5,000 to 7,000 people are expected Saturday to attend the 13th annual Minco Honey Festival. a quilt show, Honey Plant tours, kids Tractor Pull, and Made in Oklahoma products. News 4’s Lucas Ross, originally from Minco, greeted and entertained shoppers looking for. MINCO What started as a small hometown festival to generate additional revenue for local businesses has turned into a statewide event attracting thousands each year. 32 nd Annual Minco Honey Festival Saturday, December 3, 202 2. Attendees will notice the aroma of food throughout town from local restaurants and food vendors. (KFOR) Visitors poured into Minco for the 29th annual Minco Honey Festival, Saturday. Honey products and gifts will be available for purchase.Īs the land of milk and honey, Minco dairy producers will have free samples of cheese and milk products. Tours of the Ross Honey Plant are given throughout the day by owners Jim and Glenda Ross. The Minco Honey Festival started thirty two years ago by the Minco Chamber of Commerce with nine craft booths. This is the place to find pure sweet Oklahoma honey from the largest honey producing facility in the state. Come for the large arts & crafts show, tours of the. Jim Ross, owner of the Ross Honey Company. Saturdays Honey Festival will feature a number of attractions. Visit Minco, Oklahoma (just a short drive from the metro) for the 31st Annual Minco Honey Festival. Since 1990, every first Saturday of December the town brings in thousands of tourists to the Christmas Honey Festival. Now the Honey Festival, Saturday, December 3, has over 90 crafters, a quilt show, Honey Plant tours, kid’s Tractor Pull, and Made in Oklahoma products. By Jayson Knight Minco FFA members have worked hard during the. minco ok hone festival 2021 questions Minco Honey Festival - Oklahoma WebMinco, United States of. The Minco Honey Festival started thirty two years ago by the Minco Chamber of Commerce with nine craft booths. Minco has a fine Minco bed and breakfast. ![]() ![]() ![]() These findings highlighted the possibility that manipulation of AS might provide a potential target for cancer treatment. ![]() Nowadays, growing evidence indicates that aberrations in AS are considered a molecular hallmark of cancer 20. Cancer cells often display aberrant AS profiles, which are associated with apoptosis 16, angiogenesis 17, migration 18, and drug resistance 19. Accumulating evidence has demonstrated that dysregulated AS contributed to malignant diseases, including cancer, especially breast cancer 13, 14, 15. Therefore, effective therapeutic targets are urgently identified.Īlternative splicing (AS) is a major mechanism for generating multiple structurally and functionally different proteins from a single gene, greatly expanding proteome diversity 12. ![]() However, the efficacy of second-line chemotherapy is limited by low response rates and short progression-free survival (PFS), leading to unchanged OS among TNBC patients over the past two decades 10, 11. ![]() Owing to the absence of effective targets, systematic chemotherapy remains the mainstay of TNBC patients 9. The 5-year overall survival (OS) rate is about 80% in Chinese women 7, 8. TNBC patients often have poor clinical outcomes due to the high risk of early relapse and visceral metastases within 5 years 6. This subtype represents 15–20% of all breast cancers in Chinese women 4 and is more common in patients with younger age, African-American race, and BRCA1 germline mutations 5. Triple-negative breast cancer (TNBC), defined by a lack of expression of estrogen receptor (ER), progesterone receptor (PR) expression, and human epidermal growth factor receptor 2 (HER2), is the most aggressive subtype among breast cancers 2, 3. Conclusively, our findings provided novel insights into the anti-oncogenic mechanism of MCPIP1, suggesting that MCPIP1 could serve as an alternative treatment target in TNBC.īreast cancer is the most common malignancy and the fourth leading cause of cancer-related deaths among women in China, accounting for 19.9% of all cancer diagnosed and 9.9% of all cancer-associated deaths in females in 2020 1. Subsequently, we showed that CTF5 participated in MCPIP1-mediated antiproliferative effect by transcriptionally repressing cyclin D1 expression, as well as downregulating its downstream signaling targets p-Rb and E2F1. Furthermore, we demonstrated that MCPIP1 modulated NFIC AS to promote CTF5 synthesis, which acted as a negative regulator in TNBC cells. Mechanistically, MCPIP1 was first demonstrated to act as a splicing factor to regulate AS in TNBC cells. We demonstrated that MCPIP1 overexpression dramatically suppressed cell cycle progression and proliferation of TNBC cells in vitro and repressed tumor growth in vivo. Here, we showed that MCPIP1 was downregulated in 80 TNBC tissues and five TNBC cell lines compared to adjacent paracancerous tissues and one human immortalized breast epithelial cell line, while its high expression levels were associated with increased overall survival in TNBC patients. Monocyte chemotactic protein induced protein 1 (MCPIP1), a zinc finger RBP, functions as a tumor suppressor in many cancers. AS is generally controlled by AS-associated RNA binding proteins (RBPs). Recently, emerging evidence suggested that aberrant alternative splicing (AS) plays a crucial role in tumorigenesis and progression. Triple-negative breast cancer (TNBC) is the most aggressive subtype with the worst prognosis and the highest metastatic and recurrence potential, which represents 15–20% of all breast cancers in Chinese females, and the 5-year overall survival rate is about 80% in Chinese women. ![]() ![]() ![]() If aliens do ever land on Earth, maybe we should just send her to greet them. ![]() She also represents humankind with more dignity and grace than any other modern actor possibly could. She sweats, she cries, she bleeds, she struggles, and so much more that can’t be said here without giving away the film’s most awesome treasures. Adams is a chameleonic actress of immense talent, and Arrival lets her wear each of her various camouflages over the course of its duration. Army to figure out how the hell to communicate with our alien visitors. This is a robust but delicate work captured in stunning, calculated detail by cinematographer Bradford Young, and guided by Amy Adams’ stellar work as Louise Banks, a brilliant linguist commissioned by the U.S. You can also engage with it for its subtext, should you actually look for it. You can engage with Arrival for its text, which is powerful, striking, emotive and, most of all, abidingly compassionate. Fundamentally, it’s about the day aliens make landfall on Earth, and all the days that come after-which, to sum up the collective human response in a word, are mayhem. It’s both the full embodiment of Villeneuve’s approach to cinema and a marvelous, absorptive piece of science fiction, a two hour sleight-of-hand stunt that’s best experienced with as little foreknowledge of its plot as possible. Your appreciation of Denis Villeneuve’s Arrival will hinge on how well you like being led astray. Stars: Amy Adams, Jeremy Renner, Forest Whitaker, Michael Stuhlbarg How can any of us save a place like Detroit? In Robocop, it’s a deeply personal matter. As Verhoeven passed a Christ-like cyborg-a true melding of man and savior-through the crumbling post-apocalyptic fringes of a part of the world that once held so much prosperity and hope, he wasn’t pointing to the hellscape of future Detroit as the battlefield over which the working class will fight against the greedy 1%, but instead to the robot cop, to Murphy (Peter Weller), as the battlefield unto himself. He made Detroit’s decay tactile, visceral and immeasurably loud, limning it in ideas about the limits of human identity and the hilarity of consumer culture. By 1987, much of the city was already in complete disarray, the closing of Michigan Central Station-and the admission that Detroit was no longer a vital hub of commerce-barely a year away, but its role as poster child for the Downfall of Western Civilization had yet to gain any real traction. A practically peerless, putrid, brash concoction of social consciousness, ultra-violence and existential curiosity, Paul Verhoeven’s first Hollywood feature made its tenor clear: A new industrial revolution must take place not within the ranks of the unions or inside board rooms, but within the self. And so, though it was filmed in Pittsburgh and around Texas, Detroit is the only logical city for a Robocop to inhabit. The impact of such a massive tectonic shift in the very foundation of the auto industry pushed aftershocks felt, of course, throughout the Rust Belt and the Midwest-but for Detroit, whose essence seemed composed almost wholly of exhaust fumes, the change left the city in an ever-present state of decay. ![]() Broadly speaking, of course: Manufacturing was booming, but the homegrown “Big Three” automobile companies in Detroit-facing astronomical gas prices via the growth of OPEC, as well as increasing foreign competition and the decentralization of their labor force-resorted to drastic cost-cutting measures, investing in automation (which of course put thousands of people out of work, closing a number of plants) and moving facilities to “low-wage” countries (further decimating all hope for a secure assembly line job in the area). ![]() Throughout the late-’70s and indulgent 1980s, “industry” went pejorative and Corporate America bleached white all but the most functional of blue collars. Stars: Peter Weller, Nancy Allen, Miguel Ferrer, Ronny Cox, Kurtwood Smith Here are the 20 best sci-fi movies streaming on Amazon Prime: You may also want to consult the following, sci-fi centric lists: And also, you can watch The Tomorrow War if you feel really inclined. We’ve dug through pages and pages of free sci-fi offerings for Amazon Prime members and found a handful worth your time, from hilarious satires to graphically violent satires, from iconic, controversial picks to a few from as recently as last year. The sci-fi movie selection on Amazon Prime isn’t what it used to be, but the selections it does have are all over the map-classic sci-fi from the 1970s and ’80s, recent blockbusters, indie gems-and representative of such a dearth of quality, buttressed by butt-loads of low-budget B-movies, that browsing for the good stuff is more than difficult. ![]() ![]() ![]() ![]() Not only are the mints easy to grow, they hold their flavor well and can be brewed fresh or dried long after the harvest has waned. ( Mentha spp.) If you grow one plant in your herbal tea garden, make it a mint. Even if your garden is small and you can’t grow the variety of fruits and herbs available in today’s teas, you can still grow your own streamlined versions bursting with flavor and costing mere pennies. Tea connoisseurs with a green thumb and some growing space can now grow enough plants and shrubs to supply their pantries year round. Globalization, along with artisanal tea shops popping up all over the map, have helped people see the benefits of consuming more and different beverages in tea form.īut are these aromatic blends gracing the shelves of your local teashop possible to grow at home? Many people certainly think so. Across the world, teas made from a wide variety of plants have a long history of medicinal and culinary use. Her tea came in tins or boxes, and was first rolled, oxidized, and fermented to a dark chocolate brown before finding its way across oceans and into her pot.Īcross the world, teas made from a wide variety of plants have a long history of medicinal and culinary use.Īlthough many people would still agree with my grandmother, the West’s definition of tea has expanded considerably in recent years. Raised from proud British stock, she only ever considered one beverage worthy of the moniker tea, and that was the one brewed from the plant Camellia sinensis. “There is tea, and then there is tea,” my grandmother used to say when she was drinking one of the many herbal concoctions I served her. ![]() ![]() ![]() Beta Alanine which increases endurance by fighting off muscle fatigue by delaying the accumulation of lactic acid in your muscles. ![]() In a clinical trial, subjects taking the Peak ATP gained 90% more muscle than those who didn’t, and they increased their strength by 147%. Peak ATP which provides great muscle pumps as well as the kind of muscle energy that makes you work harder than you thought possible.Caffeine for the energy boost and increased focus.Grains of Paradise which can help burn fat and increase energy.Holy Basil an adaptogenic herb that helps increase muscle mass.Ecklonia Cava which contains important polyphenols called Phlorotannins.The MuscleTech website provides not only a complete ingredient list, but they also explain how most of the key ingredients work to help you work your hardest and gain real muscle mass. ![]() MuscleTech #Shatter SX-7 Ingredients and How They Work Let’s take a look at the formula to see if they’re likely to pan out. Sounds perfect, but claims are just that. In fact, it claims to increase your muscle strength by 147% and help you gain almost 9 pounds of lean muscle in just 12 weeks. It serves its pre workout purpose of providing energy and stamina, but it also includes provides added benefits that help you build muscle mass. MuscleTech #Shatter SX-7 is a pre workout supplement designed specifically to help you put on muscle mass. The first thing they usually go for is a stimulant-based pre workout to get them motivated to keep going through the rough spots.īut what happens when you’ve gotten through that rough beginning, when you’re solidly past the first steps of getting in shape?įor a lot of guys, that’s when it’s time to start bulking up. They probably want to lose that layer of fat they’ve seen creeping up for the past couple months or years. When people first start thinking about taking supplements to help get the most out of their workouts, they usually start out with the basics. ![]() ![]() ![]() ![]() ![]() The general idea is that both horizontal and vertical tiles make the space appear larger, which is accurate at some point. The visual differences between horizontal and vertical waterfall tiles are significant, and designers use them tactfully in various settings. In most shower areas, both horizontal and vertical waterfall tile layouts are used. Horizontal Or Vertical Waterfall Tile Layout? These tiles are excellent for areas that are looking to be in complete sync with the bathroom architecture and environment surrounding them. Moreover, waterfall tiles offer a polished surface that reacts well with shifting light by imitating the textural variances and color changes of shimmering ancient rock. Waterfall tile colors are often grayscale and range from the darkest, “deep stream,” to the lightest, “ivory stream.” This evokes the natural oxidative degradation of stone, a material that is always changing color, shape, and structure while adjusting to the progression of natural phenomena. Waterfall designs can be created using planks, little square glass mosaics, subway tiles, and a variety of other materials. They attract your attention to a focal point in your shower, providing depth and character. Waterfall tiles are an excellent choice for creating a centerpiece for shower surrounds. They are also ideal for those who want to create a soothing atmosphere for their guests or family members. The design of waterfall shower tiles is a great way to make your shower space look like a relaxing bathroom sauna. This design was made popular by the ancient Romans who used it in their baths and fountains. It is also known as a listel in French or listello in Italian. This has become a popular way to add beauty, creativity, shimmer, and complexity to the shower wall. Most homeowners are drawn to this style of bathroom tile installation when they want to create a pampering environment or have a Feng Shui sense of style.Ī waterfall-tiled shower layout is inspired by the commonly used horizontal ornamental tile banding that has existed since the Roman-style bathrooms. The tile is usually vertically placed to give the design character and uniqueness.Įven when the shower is turned off, it contributes to the illusion of an actual waterfall. How Wide Should Shower Waterfall Accent Tile Be?Ī waterfall style is generally a tile accent positioned directly around the primary shower head.Horizontal Or Vertical Waterfall Tile Layout?. ![]() ![]() ![]()
![]() ![]() The remaining crystals are trimmed with our exclusive European crystals which are precision cut like diamonds offering a competitively priced fixture using quality crystal components. ![]() This option allows you to own a fixture that partially trimmed with octagonal shaped Swarovski® Spectra® crystals. crafted of brass in a shape reminiscent of a bamboo stick, while the top is in. Free Shipping Charming metal set of nesting tables that are made to look like cane and bamboo Beautiful set for outdoor or indoor spaces. ![]() A brilliant Precision cut crystal with superior light reflection that produces beautiful rainbows.Ĭombination of European & Swarovski Crystal: Versatile and elegant, this set of three side tables can be displayed. This luxurious crystal can be found in the most prestigious estates around the world. Manufactured in Austria by Swarovski® these are one of the highest quality crystals the market. Own a Swarovski look at a much more affordable price point. Often compared to Swarovski® for its clarity and brilliance. Featuring clean, simple lines with tapered spindle legs and spacious round tops, this accent table set fits flawlessly with everything from your mid-century modern coffee table and Scandinavian nightstand to contemporary side tables and modern shelving. Precision cut like diamonds, the European crystal option offers a quality crystal at an affordable price point.Īsfour crystals are made in Egypt and is the most popular crystal brand in the world mainly because of the price and quality. Bring the best of style and function to your home with this Two-Piece Nesting End Tables Set by Lavish Home. Sourced from Austria, Czech Republic & various parts of Europe. Many of our Fixtures are available in a variety of Crystal Trim options.Įxclusive to WeGotLites! These Fixtures are trimmed with quality Crystals that sparkle beautifully. The quantity and shapes of the Crystal used to trim the fixture and like grades of diamonds, the crystal quality determines the price. In most designs, the major cost of a Crystal Fixture is the price of the Crystal components. ![]() |
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